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Despite the questionable effectiveness of opioids in controlling CNCP as well as their large prices of Unintended effects, the absence of obtainable substitute medications and their scientific constraints and slower onset of motion has resulted in an overreliance on opioids. Serious pain is chal

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These effects, together with a prior report exhibiting that a small-molecule ACKR3 agonist CCX771 displays anxiolytic-like behavior in mice,two help the principle of focusing on ACKR3 as a unique technique to modulate the opioid method, which could open new therapeutic avenues for opioid-related